I have hepatitis C, can I get a Vivitrol shot? Addiction Treatment Centers, MA Leave a comment

They usually offer HIV/hepatitis C tests and can offer linkage to getting treatment for the addiction as well as the infectious disease or diseases. Breakthrough drugs such as Sovaldi and Harvoni can actually cure hepatitis C in as little as three months. These treatments are a far cry from old-line treatments such as interferon and ribavirin that had harsh side effects and proved ineffective for many, especially those people co-infected with HIV. HIV is a manageable chronic illness thanks to modern highly active antiretroviral therapy .

vivitrol and hep c

You assume full responsibility for the communications with any healthcare provider you contact through the Provider Locator. Alkermes shall in no event be liable to you or to anyone for any decision made or action taken by you in the reliance on information. While an addicted person may not always be able to see or care how an addiction can cripple his or her life socially and financially, letting a deadly disease go untreated can only have one indisputable outcome. Finding the right treatment program can help you or your loved one begin the journey toward a healthier, sustainable recovery. Needle exchanges are scientifically proven as a way to stop the spread of HIV and hepatitis C.

These findings would have been further strengthened by comparison to a group of participants who were not on MOUD; however, the parent cohort studies were not powered to assess for this difference. Our secondary outcomes were change in opioid IDU and stimulant use among the whole cohort and by HIV serostatus from baseline to 90 days after initiation of MOUD. Self-reported injection opioid use was assessed from TLFB data collected at baseline and at 90-day follow-up after initiating MOUD and defined as mean proportion of opioid IDU over 30 days.

In the SPRINT-1, SPRINT-2, and RESPOND-2 trials of boceprevir, 20 patients on methadone received PegIFN/RBV plus boceprevir and four received PegIFN/RBV plus placebo. In the boceprevir group, SVR rates were 50% in the 20 patients on methadone versus 63% in the 1528 patients not on methadone. In the placebo group, SVR rates were 25% in the four patients on methadone versus 37% in the 543 patients not on methadone48. Given the limited number of patients involved it is difficult to draw conclusions from this data but SVR rates were broadly comparable.49. About a third of people can clear the virus within six months, Conkle added, however, the ones that don’t are most likely going to develop chronic hepatitis and will be at risk for cancer and cirrhosis.

What are other possible serious side effects of VIVITROL?

Loperamide, which is found in some OTC antidiarrheal medications. Examples include products made by Imodium and Pepto-Bismol. Research has also found that using loperamide for opioid withdrawal can also increase the risk of cardiac emergencies. In fact, some healthcare professionals suggest that continued use of alcohol or opioids can pose more danger to health than taking naltrexone.

  • The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions.
  • Medicines or street drugs, your healthcare provider may give you a small injection of a medicine called naloxone.
  • Acetaminophen , which may increase naltrexone’s effects on your liver.

Because many persons on OAT continue to inject and use drugs, we propose that a strategy of treatment and cure-as-prevention is imperative in this population to curb the hepatitis C epidemic in the US. Failure to complete the evaluation process once linked to care, and physician-perceived patient risk factors as contraindications to therapy have been amongst the most common reasons patients are not considered for HCV treatment69–71. Liver biopsies are now rare, which should further reduce the barrier to pretreatment staging among PWIDs and patients on OAT. Fears that patients on OAT or active PWIDs may have low adherence to HCV therapy may also result in low HCV treatment rates.

Directly Observed Therapy

Before taking naltrexone, tell your doctor about any OTC medications you take, as well as supplements and herbs. You will also be required to stop taking opioids 7 to 10 days before starting this medication. Continued alcohol consumption is particularly concerning if you have a liver disease such as HCV. It may increase your risk for further complications, such as cirrhosis and cancer of the liver. An increase in liver enzymes that may indicate liver disease has been observed in some people taking naltrexone. The way that naltrexone may cause liver damage is currently unknown.

vivitrol and hep c

Mauss S, Klinker H. Drug-drug interactions in the treatment of HCV among people who inject drugs. Chatterjee S, Tempalski B, Pouget ER, Cooper HL, Cleland CM, Friedman SR. Changes in the prevalence of injection drug use among adolescents and young adults in large U.S. metropolitan areas. Published clinical studies evaluating HCV treatment outcomes among patients on OAT. By using OTC or prescription opioids while taking naltrexone, there is also an increased risk of opioid overdose.

It is not known if VIVITROL passes into your milk, and if it can harm your baby. Naltrexone, the active ingredient in VIVITROL, is the same active ingredient in tablets taken by mouth that contain naltrexone. Talk to your healthcare provider about whether you will breastfeed or take VIVITROL. Tell your healthcare provider about any reaction at an injection site that concerns you, gets worse over time, or does not get better within two weeks.

What is the most important information I should know about VIVITROL?

However, studies in the IFN era showed similar adherence in patients with and without a history of drug use42,47,72. In one study of 71 patients maintained on methadone and treated with PegIFN/RBV, intermittent drug users were similarly adherent to those alcohol and cancer risk fact sheet strictly abstinent from illicit drugs73. In the era of DAAs, one study of 61 methadone maintained patients on sofosbuvir-based regimens showed that mean weekly adherence by electronic monitors was 88% and mean adherence by visual analog scale was 95%.

vivitrol and hep c

Your comment will be reviewed and published at the journal’s discretion. The funders were not involved in the research design, analysis or interpretation of the data, or the decision to publish the manuscript. Are allergic to naltrexone or any of the ingredients in VIVITROL or the liquid used to mix VIVITROL .

Group Treatment

Opioid treatment programs , such as methadone maintenance programs, provide opioid agonist therapy to more than 300,000 opioid-dependent patients in the US10. Buprenorphine is also widely prescribed for OAT, primarily outside of OTPs and in the outpatient medical setting. More than twice as many people are prescribed buprenorphine than methadone nationwide11,12 and 9.3 million buprenorphine prescriptions were filled in the United States in 2012 alone13. Approximately 70% of patients on OAT are HCV antibody positive14–16, and many continue to use and inject drugs while in drug treatment17,18. In some cases, injection drug users learn they are infected with both diseases at the same time.

Of the eight patients in these cases, all were former drug users and two received OAT72,91. Graft survival, patient survival, and rejection rates were similar in former IDUs compared with non-IDUs72, and of the two patients treated for HCV, one patient achieved SVR and remained infection free four years post-transplant72,91. While intraoperative anesthesia and post-operative analgesia can present a challenge in patients on OAT, collaboration with pain specialists can help remove this as a barrier to care91. Multiple models suggest that even a moderate increase in HCV treatment uptake and cure in PWIDs will reduce overall HCV prevalence, with potential HCV disease eradication27–29.

The phrase “one size fits all” may apply to some things; baseball caps, ponchos, and theatre seats come to mind. It does NOT, however, apply to the medical treatment of opioid use disorder and the accompanying disease Hepatitis C, known as HCV. Assessment of drug-drug interactions between daclatasvir and methadone or buprenorphine-naloxone.


There are significant risks from VIVITROL treatment, including risk of opioid overdose, severe reaction at the injection site, sudden opioid withdrawal, liver damage, or hepatitis. Talk to your healthcare provider about naloxone, a medicine that is available to patients for the emergency treatment of an opioid overdose. Mauss S, Berger F, Goelz J, Jacob B, Schmutz G. A prospective controlled study of interferon-based therapy of chronic hepatitis C in patients on methadone maintenance.

On-site HCV peer programs for patients who co-facilitate support groups should be considered. Make regular HCV support groups available on-siteIdeally, support groups should be co-facilitated by staff members (medical or non-medical) and patients. Clinical registries should be created to ensure that case management is provided alcohol allergy & alcohol intolerance for patients with HCV who are not currently engaging in care. If confirmation with an HCV viral load cannot be performed, HCV-antibody positive patients should be referred to a clinic where HCV RNA measurement can be done.Case managers, patient navigators, or peer escorts may facilitate adherence to follow-up visits.

A meta-analysis of 19 studies of PWIDs treated with PegIFN/RBV considered the effect of HCV GT, HIV coinfection, and the involvement of a multidisciplinary team on SVR. In a multivariate analysis they showed that involvement of a multidisciplinary team improved SVR rates (P38. Medicines or opioid signs of a functioning alcoholic street drugs, it is important that you tell your healthcare provider before starting VIVITROL to avoid having sudden opioid withdrawal symptoms when you start VIVITROL treatment. Medicines or street drugs, your healthcare provider may give you a small injection of a medicine called naloxone.

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